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The Annexin A1 Receptor FPR2 Regulates the Endosomal Export of Influenza Virus

Identifieur interne : 000132 ( Main/Exploration ); précédent : 000131; suivant : 000133

The Annexin A1 Receptor FPR2 Regulates the Endosomal Export of Influenza Virus

Auteurs : Fryad Rahman [France] ; Mohammad Chebbo [France] ; Noemie Courtin [France] ; Aurelien Fotso Fotso [France] ; Marie-Christine Alessi [France] ; Beatrice Riteau [France]

Source :

RBID : Hal:hal-02091328

English descriptors

Abstract

The Formyl Peptide Receptor 2 (FPR2) is a novel promising target for the treatment of influenza. During viral infection, FPR2 is activated by annexinA1, which is present in the envelope of influenza viruses; this activation promotes virus replication. Here, we investigated whether blockage of FPR2 would affect the genome trafficking of influenza virus. We found that, upon infection and cell treatment with the specific FPR2 antagonist WRW4 or the anti-FPR2 monoclonal antibody, FN-1D6-AI, influenza viruses were blocked into endosomes. This effect was independent on the strain and was observed for H1N1 and H3N2 viruses. In addition, blocking FPR2signaling in alveolar lung A549 epithelial cells with the monoclonal anti-FPR2 antibody significantly inhibited virus replication. Altogether, these results show that FPR2signaling interferes with the endosomal trafficking of influenza viruses and provides, for the first time, the proof of concept that monoclonal antibodies directed against FPR2 inhibit virus replication. Antibodies-based therapeutics have emerged as attractive reagents in infectious diseases. Thus, this study suggests that the use of anti-FPR2 antibodies against influenza hold great promise for the future.


Url:
DOI: 10.3390/ijms19051400


Affiliations:

Links toward previous steps (curation, corpus...)

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<author>
<name sortKey="Riteau, Beatrice" sort="Riteau, Beatrice" uniqKey="Riteau B" first="Beatrice" last="Riteau">Beatrice Riteau</name>
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<orgName type="acronym">INRA</orgName>
<date type="start">1946-05-18</date>
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<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc>
<address>
<addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
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<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc>
<address>
<addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
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<country>France</country>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.3390/ijms19051400</idno>
<series>
<title level="j">International Journal of Molecular Sciences</title>
<idno type="ISSN">1422-0067</idno>
<imprint>
<date type="datePub">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="mix" xml:lang="en">
<term>Annexin A1</term>
<term>FPR2</term>
<term>influenza</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>The Formyl Peptide Receptor 2 (FPR2) is a novel promising target for the treatment of influenza. During viral infection, FPR2 is activated by annexinA1, which is present in the envelope of influenza viruses; this activation promotes virus replication. Here, we investigated whether blockage of FPR2 would affect the genome trafficking of influenza virus. We found that, upon infection and cell treatment with the specific FPR2 antagonist WRW4 or the anti-FPR2 monoclonal antibody, FN-1D6-AI, influenza viruses were blocked into endosomes. This effect was independent on the strain and was observed for H1N1 and H3N2 viruses. In addition, blocking FPR2signaling in alveolar lung A549 epithelial cells with the monoclonal anti-FPR2 antibody significantly inhibited virus replication. Altogether, these results show that FPR2signaling interferes with the endosomal trafficking of influenza viruses and provides, for the first time, the proof of concept that monoclonal antibodies directed against FPR2 inhibit virus replication. Antibodies-based therapeutics have emerged as attractive reagents in infectious diseases. Thus, this study suggests that the use of anti-FPR2 antibodies against influenza hold great promise for the future.</p>
</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>France</li>
</country>
<region>
<li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement>
<li>Marseille</li>
</settlement>
<orgName>
<li>Université d'Aix-Marseille</li>
</orgName>
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<tree>
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<region name="Provence-Alpes-Côte d'Azur">
<name sortKey="Rahman, Fryad" sort="Rahman, Fryad" uniqKey="Rahman F" first="Fryad" last="Rahman">Fryad Rahman</name>
</region>
<name sortKey="Alessi, Marie Christine" sort="Alessi, Marie Christine" uniqKey="Alessi M" first="Marie-Christine" last="Alessi">Marie-Christine Alessi</name>
<name sortKey="Chebbo, Mohammad" sort="Chebbo, Mohammad" uniqKey="Chebbo M" first="Mohammad" last="Chebbo">Mohammad Chebbo</name>
<name sortKey="Courtin, Noemie" sort="Courtin, Noemie" uniqKey="Courtin N" first="Noemie" last="Courtin">Noemie Courtin</name>
<name sortKey="Fotso, Aurelien Fotso" sort="Fotso, Aurelien Fotso" uniqKey="Fotso A" first="Aurelien Fotso" last="Fotso">Aurelien Fotso Fotso</name>
<name sortKey="Riteau, Beatrice" sort="Riteau, Beatrice" uniqKey="Riteau B" first="Beatrice" last="Riteau">Beatrice Riteau</name>
</country>
</tree>
</affiliations>
</record>

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